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Org by HINARI on 08/27/07. For personal use only. 38 HENKART evidence for a secretory process involving the cytoplasmic granules. Henkart & Henkart (1) described the fusion of NKeffector cell granules with each other and the release of granule contents into the space between effector and target cells after incubation at 37° of NKconjugates. The exocytosed material contained cylindrical structures with an inner diameter of 15 nmthat were previously identified on target membranesafter LGL-mediatedkilling (see below).

Exp. Med. 135:357-75 Chase, M. , Maguire, H. C. Jr. 1973. XIV. Further studies on sensitization of guinea pigs with picric acid. Int. Arch. Aller(ty Appl. Immunol. 45:513-42 Chase, M. W. 1976. Developments in Delayed-Type Hypersensitivities, 19501975. J. Invest. Dermat. 67:136 Polak, L. 1977. Immunological aspects of contact sensitivity. In Advances in Modern Toxicolo~ly, Vol. 4 : Dermatotoxicology and Pharmacology, ed. F. N. Marzulli, H. I. Maibach,p. 225. Washington DC: Hemisphere Annu. Rev. Immunol.

Proyr. Allergy 10:151 18. Chase, M. W. 1945. The cellular transfer of cutaneous hypersensitivity to tuberculin. Proc. Soc. Exp. Biol. 59 : 134 19. Kirchheimer, W. , Weiser, R. S. 1947. The tuberculin reaction. I. Passive transfer of tuberculin sensitivity with cells of tuberculous guinea pigs. Proc. Soc. Exp. Biol. 66 : 166 20. Jacobs, J. , Golden, T. , Kelly, J. J. 1940. Immediate reactions, to anhydrides, of wheal-and-erythematype. Proc. Soc. Exp. Biol. 43 : 74 21. L. 1940. Immediategeneralized reactions in hypersensitive guinea pigs.

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