Download Cellular Senescence and Tumor Suppression by Laura Gardano, Lea Harrington (auth.), Peter D. Adams, John PDF

By Laura Gardano, Lea Harrington (auth.), Peter D. Adams, John M. Sedivy (eds.)

Leonard Hayflick and co-workers coined the time period "cellular senescence" to explain the inevitable and irreversible proliferation arrest of fundamental human cells in tradition. particularly, Hayflick and coworkers pronounced the phenomenon of replicative senescence in fundamental human fibroblasts, displaying that those cells can proliferate in vitro for roughly fifty five inhabitants doublings prior to their proliferative skill succumbs to irreversible proliferation arrest.

Since these unique observations, significant advances in our figuring out have are available in numerous parts. We now recognize that a number of different triggers, as well as proliferative exhaustion, can set off the senescence application. One very important type of senescence triggers, and attention of this quantity, are activated oncogenes in basic untransformed cells. there's now strong proof to point that senescence in keeping with this cue is a powerful tumor suppressor mechanism, via its skill to dam proliferation of incipient melanoma cells. even though, senescence isn't easily a passive proliferation arrest that affects in simple terms the senescent mobile itself, yet relatively, senescent cells effect their setting and neighboring cells via an lively secretory application. This secretory application seems to be to facilitate senescence as a tumor suppression method.

Cellular Senescence and Tumor Suppression collects a couple of chapters from leaders within the box to check the molecular foundation of senescence and its physiological services, with a selected emphasis at the position of senescence in tumor suppression.

Show description

Read or Download Cellular Senescence and Tumor Suppression PDF

Similar nonfiction_2 books

Tropical Alpine Environments: Plant Form and Function

Tropical alpine environments (at altitudes above the closed cover woodland and lower than the restrict of flora) current an strange set of advanced stresses for plant species. not like temperate alpine environments, the place there are designated seasons of favorable and adverse stipulations for development, tropical alpine habitats current summer season stipulations each day and iciness stipulations each evening.

Additional info for Cellular Senescence and Tumor Suppression

Example text

DNA Repair (Amst) 3(3):225–233 Bakkenist CJ, Kastan MB (2003) DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation. Nature 421(6922):499–506 Baumann P, Cech TR (2001) Pot1, the putative telomere end-binding protein in fission yeast and humans. Science 292(5519):1171–1175 Baur JA, Zou Y et al (2001) Telomere position effect in human cells. Science 292(5524):2075–2077 Beattie TL, Zhou W et al (1998) Reconstitution of human telomerase activity in vitro. Curr Biol 8(3):177–180 Beattie TL, Zhou W et al (2001) Functional multimerization of the human telomerase reverse transcriptase.

Budding yeast has a very large RNA component in which the 5¢ end of the template is established by Helix H1 located immediately upstream of the template sequence (Tzfati et al. 2000). Interestingly, studies in Kluyveromyces revealed the presence of a pseudoknot containing two conserved sequences (CS)3 and 4 that regulate telomerase activity. Mutations in these regions affect telomerase catalysis and result in a template shift causing the misincorporation of nucleotides during the in vitro telomerase reaction (Tzfati et al.

2001). Longer telomeres have longer heterochromatic sequences close to the telomere, suggesting that the aging phenotype associated with short telomeres might also be a result of a change of transcription in these regions (Baur et al. 2001). In fission yeast, the silencing mechanism also involves the siRNA machinery, but mutation of the RNA machinery does not have an influence on telomere length (Kanoh et al. 2005). On the contrary, in Drosophila the involvement of the siRNA system is conserved, but its alteration shows an effect on the transposition mechanisms responsible for telomere elongation (Volpe et al.

Download PDF sample

Rated 4.99 of 5 – based on 43 votes